Coronary Heart Disease

Hypertension

Interventional Cardiology

Preventive

410-955-9864

Volunteers with Stable High Blood Pressure Are Needed for a 28 week Research Study with Oral  Tadalafil (IRB # NA00001634)

We are enrolling men and women 30-85 years old with high blood pressure for a 6 month study comparing the effects of Cialis® (Tadalafil) with a placebo (inactive substance) on the heart.  Tadalafil is a medicine similar to Viagra® that is commonly used to treat male erectile dysfunction.

Participation involves a screening visit with ultrasound testing and examination.  If eligible, volunteers will receive daily study drug and come to Johns Hopkins Hospital for monthly visits with exercise testing, ultrasound, and MRI of the heart.

To be in this study you must meet the following qualifications:

      1.   Male or female age 30-85 years old
      2.   Have high blood pressure
      3.   Have thickened heart muscle due to high blood pressure
      4.   Normal ejection fraction (EF ≥ 50%)
      5.   50% of subjects will have diabetes

Eligible volunteers will receive $40.00 per completed study visit, and a parking voucher on the day of their visits.