Cardiomyopathy and Heart
Failure

Interventional

Preventive

Donald W. Reynolds Center
for Cardiovascular Research

Vascular

Principal Investigator: Henry R. Halperin, MD

Laboratory Manager: Dr. Menekhem M. Zviman

• Magnetic Resonance Guidance of Catheter Based Ablation for Cardiac Arrhythmia
• Clinically Indicated Magnetic Resonance Imaging of Patients with Permanent Pacemakers and Implantable Cardioverter Defibrillators
• Magnetic Resonance Assessment of Cardiac Structure, Function, and Risk of Arrhythmia in Myotonic Dystrophy
• Ventricular Maze Ablation to Increase the Ventricular Fibrillation Induction Threshold
• Magnetic Resonance Imaging of Circumferential Pulmonary Vein Ablations for Atrial Fibrillation
• Magnetic Resonance Characterization of Cardiac Anatomy in Patients at Risk for Sudden Cardiac Death

Dr. Ronald D. Berger
Dr. Gordon F. Tomaselli
Dr. Hugh Calkins
Dr. Saman Nazarian

1. Borhan, B.; Nazarian, S.; Stocking, E.M.; Kurth, M.J.; Hammock, B.D.; An efficient preparation of 18O-labeled epoxides; Journal of Organic Chemistry, 59, 15:  4316-4318, 1994.

2. Borhan, B.; Mebrahtu, T.; Nazarian, S.; Kurth, M.J.; Hammock, B.D.; Improved radiolabeled substrates for soluble epoxide hydrolase; Analytical Biochemistry, 231, 1:  188-200, 1995.

3. Kantorowski, E. J.; Borhan, B.; Nazarian, S.; Kurth, M.J.; Cyclopropylcarbinyl radical mediated ring expansion to seven membered carbocycles; Tetrahedron Letters, 39, 2483-2486, 1998.

4. Qiu, D.;  Zhao, G.;  Aoki, Y.;  Shi, L.;  Uyei, A.;  Nazarian, S.;  Ng, J.C.;  Kao, P.N.;  Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kB transcriptional activation, Journal of Biological Chemistry, 274, 19: 13443-13450, 1999.

5. Nazarian, S.; Knight, BP; Dickfeld; T.L; Zviman, M.M; Jayanti, V.B.; Amundson, D.; Hanlin, J.; Castleberry, J.; Smith, M.F.; Blankenship, L.; Halperin, H.R.; Ferguson, T.B.; Berger, R.D.; Direct Visualization of Coronary Sinus Ostium and Branches with a Flexible Steerable Fiberoptic Infrared Endoscope, Heart Rhythm, 2: 844-848, 2005.

6. Knight, B.P.; Burke, M.C.;Hong, T.E.; McAuley, A.; Amundson, D.; Hanlin, J.; Blankenship, L.; Ferguson, T.B.; Nazarian, S.; Berger, R.D.; Direct imaging of transvenous radiofrequency cardiac ablation using a steerable fiberoptic infrared endoscope, Heart Rhythm, 2:1116 –1121, 2005.

7. Nazarian, S.; Maisel, W.H.; Miles, J.S.; Tsang, S.; Stevenson, L.W.; Stevenson, W.G.; Impact of Defibrillators in Advanced Heart Failure, American Heart Journal, 150(5): 955-60, November 2005.

8. Nazarian, S.; Bluemke, D.A.; Lardo, A.C.; Zviman, M.M.; Watkins, S.P.; Dickfeld, T.L.; Meininger, G.R.; Roguin, A.; Calkins, H.; Tomaselli, G.F.; Weiss, R.G.; Berger, R.D.; Lima, J.A.C.; Halperin, H.R.; Magnetic Resonance Assessment of the Substrate for Inducible Ventricular Tachycardia in Non-Ischemic Cardiomyopathy, Issue Highlights, Circulation, 112(18): 2821-5, November 1, 2005.

9. Lardo, A.C.; Cordeiro, M.A.; Silva, C.; Amado, L.C.; George, R.T.; Saliaris, A.P.; Schuleri, K.H.; Fernandes, V.R.; Zviman, M.; Nazarian, S.; Halperin, H.R.; Wu, K.C.; Hare, J.M.; Lima, J.A.; Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: Characterization of myocyte death, microvascular obstruction, and chronic scar, Circulation. 2006 Jan 24;113(3):394-404.

10. Cheema, A,; Dong, J.; Dalal, D.; Vasamreddy, C.R.; Marine, J.E.; Henrikson, C. A.; Spragg, D.; Cheng, A.; Nazarian, S.; Sinha, S.; Halperin, H.; Berger, R.; Calkins, H. Long-Term Safety and Efficacy of Circumferential Ablation with Pulmonary Vein Isolation. Journal of Cardiovascular Electrophysiology, 2006; 17 (10), 1080-1085.

11. Cheema, A.; Vasamreddy, C.R.; Dalal, D.; Marine, J.E.; Dong, J.; Henrikson, C.A.; Spragg, D.; Cheng, A.; Nazarian, S.; Sinha, S.; Halperin, H.; Berger, R.; Calkins. H. Long-term single procedure efficacy of catheter ablation of atrial fibrillation. Journal of Cardiovascular Electrophysiology, 2006 Apr; 15(3):145-55. 

12. Nazarian, S.; Roguin, A.; Zviman, M.M.; Lardo, A.C.; Dickfeld, T.L.; Calkins, H.; Berger, R.D.; Bluemke, D.A.; Halperin, H.R.; Clinical Utility and Safety of a Protocol for Non-Cardiac and Cardiac Magnetic Resonance Imaging of Patients with Permanent Pacemakers and Implantable Cardioverter Defibrillators at 1.5 Tesla, Issue Highlights, Circulation, 2006 Sep; 114:1277-1284.

13. Dickfeld, T.; Kato, R.; Zviman, M.; Nazarian, S.; Dong, J.; Ashikaga, H.; Lardo, A.C.; Berger, R.D.; Calkins, H.; Halperin, H.; Characterization of acute and subacute radiofrequency ablation lesions with nonenhanced magnetic resonance imaging, Heart Rhythm. 2007 Feb; 4(2): 208-14.

14. Cheema, A.; Dong, J.; Dalal, D.; Marine, J.E.; Henrikson, C.A.; Spragg, D.; Cheng, A.; Nazarian, S.; Bilchick, K.; Sinha, S.; Scherr, D.; Almasry, I.; Halperin, H.; Berger, R.; Calkins, H.; Incidence and Time Course of Early Recovery of Pulmonary Vein Conduction after Catheter Ablation of Atrial Fibrillation, J Cardiovasc Electrophysiol. May 2007; 18: 1-5.