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Home > Research Areas > Heart Failure > The Effects of Obesity on the Cardiovascular System
The Effects of Obesity on the Cardiovascular System
 
Contact Information:Lili A. Barouch, M.D.
(410) 502-0188
 
Laboratory Location:Ross 1050
Research Focus:

Neurohormonal mechanisms of cardiac hypertrophy
The effects of obesity on the cardiovascular system

Funding Support:NIH/NHLBI
WW Smith Foundation
Active Projects:

The interaction between leptin and the beta-3 adrenergic receptor in cardiac myocyte signaling

The effect of leptin deficiency on cardiac responses to chronic intermittent hypoxia as a model of sleep apnea

Response of beta3 adrenergic receptor knockout mice to pressure overload hypertrophy via transverse aortic banding

Laboratory Collaborators:

Dan E. Berkowitz, M.D.
David A. Kass, M.D.
Christopher P. O'Donnell, Ph.D.

Selected Bibliography:

Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JAC, Berkowitz DE, Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms.  Nature 416:337-339; 2002.

Barouch LA, Cappola TP, Harrison RW, Crone JK, Burnett AL, Hare JM. Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.  Journal of Molecular and Cellular Cardiology 35:637-644; 2003.

Cappola TP, Cope L, Cernetich A, Barouch LA, Irizarry RA, Parmigiani G, Durrani S, Lavoie T, Hoffman EP, Ye SQ, Garcia JGN, Hare JM.  Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy.  Physiological Genomics 14:25-34; 2003.

Barouch LA, Berkowitz DE, Harrison RW, O’Donnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice.  Circulation. 108:754-759; 2003.

Townsend S, Jung A, Lemmon CA, Harrison RW, Li KH, Barouch LA, Cotecchia S, Shoukas A, Nyhan D, Hare JM, Berkowitz DE.  Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction.  Hypertension 44:776-782; 2004.

Minhas KM, Khan SA, Raju SV, Phan AC, Gonzalez DR, Skaf MW, Lee K, Tejani AD, Saliaris AP, Barouch LA, O’Donnell CP, Emala CW, Berkowitz DE, Hare JM. Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. Journal of Physiology 565:463-474; 2005.

Saraiva RM, Minhas KM, Raju SVY, Barouch LA, Pitz E, Schuleri KH, Vandegaer KM, Li D, Hare JM. Deficiency of neuronal nitric oxide synthase increases mortality and cardiac remodeling after myocardial infarction: Role of nitroso-redox equilibrium. Circulation 112(22):3415-22; 2005.

Barouch LA, Gao D, Chen L, Miller KL, Xu W, Phan AC, Kittleson MK, Minhas KM, Berkowitz DE, Wei C, Hare JM. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation Research 98(1):119-24; 2006.

Minhas KM, Saraiva RM, Schuleri KH, Lehrke S, Zheng M, Saliaris AP, Berry CE, Barouch LA, Vandegaer KM, Li D, Hare JM. Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy. Circulation Research 98(2):271-9; 2006.

Raju SVY, Zheng M, Schuleri KH, Phan AC, Bedja D, Saraiva RM, Yiginer O, Vandegaer K, Gabrielson KL, O'Donnell CP, Berkowitz DE, Barouch LA, Hare JM. Activation of the novel cardiac ciliary neurotrophic factor receptor reverses LVH in leptin deficient and leptin resistant obesity. Proceedings of the National Academy of Sciences USA. 103(11):4222-7; 2006.

Saraiva RM, Minhas KM, Zheng M, Pitz E, Treuer A, Gonzalez D, Schuleri KH, Vandegaer KM, Barouch LA, Hare JM. Reduced neuronal nitric oxide synthase expression contributes to cardiac oxidative stress and nitroso-redox imbalance in ob/ob mice. Nitric Oxide. In press 2006.

   

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